Banca de DEFESA: FELLIPE DE SOUZA DORNELES

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : FELLIPE DE SOUZA DORNELES
DATE: 19/01/2024
TIME: 08:30
LOCAL: Web Conferência - Google Meet:meet.google.com/dkp-uyrt-aqn.
TITLE:

Comparison of estimated glomerular filtration rate (GFR) in dogs and cats using the Cockcroft-Gault and Modification of Diet in Renal Disease (MDRD) equations.

KEY WORDS:

Injury, kidneys, serum creatinine, reference, renal function.

PAGES: 45
BIG AREA: Ciências Agrárias
AREA: Medicina Veterinária
SUMMARY:

The kidneys are extremely important organs for maintaining bodily homeostasis, with one of their main functions being the filtration and excretion of undesirable metabolites from the blood in the urine. The glomerular filtration rate (GFR) is assessed in clinical routine, through the clearance of a substance that must be completely filtered by the kidneys, the most commonly used being serum creatinine. However, it is known that serum creatinine and other more recent markers such as SDMA increase only if there is major kidney injury, when more than half of the nephrons are lost, thus making successful treatment and the animal's prognosis difficult. There are veterinary calculations for measuring creatinine clearance and thus GFR that involve the urinary and serum clearance of this marker. In Medicine, formulas are used that establish GFR based on serum creatinine, taking into account factors such as weight, sex and age of patients. Therefore, the aim of the study was to use the Cockcroft-Gault formulas, which determine GFR (mL/min), with creatinine clearance = [140-age] x (weight) x K / 72 x serum creatinine, K equivalent to 0.85 only in females, and the abbreviated Modification of Diet in Renal Disease (MDRD) equation, with GFR (mL/min/1.73m2) = 186 x (serum creatinine)-1.154 x (age)-0.203 x (0.742, if female), in addition to the Cockcroft-Gault adjusted to body surface area (CG-ASC) to establish GFR in healthy dogs and cats, which serve as reference values. The studied population consisted of healthy, male and female domestic canines and felines, who were screened to under go an elective surgical castration procedure.

COMMITTEE MEMBERS:
Presidente - 2408296 - SORAYA REGINA SACCO
Externa ao Programa - 3358765 - TABATHA DO AMARAL KALENSKI - IFCExterna à Instituição - MARIA FRANCISCA NEVES - UNICAMP