Banca de DEFESA: ANDRE MAURICIO BUZATO

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : ANDRE MAURICIO BUZATO
DATE: 24/07/2020
TIME: 14:00
LOCAL: Web Conferência via xxx - xxxx
TITLE:

Tolfenamic acid in gilts: positive effects on litters performance.

KEY WORDS:

postpartum dysgalaxia syndrome (PPD); non-steroidal anti-inflammatory drug (NSAID); hypogalaxia; zootechnical performance; piglets.

PAGES: 45
BIG AREA: Ciências Agrárias
AREA: Medicina Veterinária
SUMMARY:

Postpartum dysgalaxia syndrome (PPDS) is a common and important disorder that affects a swine female, mainly in intensive production systems. PPDS is characterized by hypogalactia in the puerperium; its symptoms may vary as fever, appetite reduction, mastitis in the female and signs of hunger in the piglets. In the majority of the cases, hypogalaxia is not clearly identified, assuming a sub-clinical aspect. Throughout the last decades, in many countries, tolfenamic acid, a nonsteroidal anti-inflammatory drug (NSAID), has been successfully administered to several animal species, as cats, dogs, cattle, and pigs. Tolfenamic acid is recognized for its analgesic, antipyretic and anti-inflammatory properties. The objective of this study was to evaluate the effect of a non-steroidal anti-inflammatory drug (NSAID), based on tolfenamic acid, as a prophylactic treatment of the syndrome of PPDS, on the zootechnical performance of the litters. Gilts (n = 332) were selected and randomly distributed in two treatments groups, n = 157 in treated group and n = 162 in the control group. Thirteen gilts were excluded during select process. The treated group received a single intramuscular injection (1 mL/20 kg tolfenamic acid/ Toldefine CS™) post-farrowing, the control group did not receive any treatment. All piglets (4,466) were weighed at first, fourth and eighteenth day of life. All litter (2,198 and 2,268 piglets for treated and control groups, respectively) were evaluated for weight gain, diarrhea occurrence, piglets and mortality between 4 and 18 days of life. Data were analyzed using the SAS program (2012), differences were considered significant at level of 5% (P <0.05). Piglet´s weight averages were analyzed by covariance considering the effect of the initial weight and the presence of diarrhea. Categorical variables were analyzed by logistic regression. The treated group had 0.41% less mortality until the 18th day of life (p = 0.0285). This rate increases to 4.5% (4.3% and 8.8% for the treated and control group, respectively) among the litters not affected by diarrhea (p = 0.0005). Gilts presenting rectal temperature above 39.5°C or mucopurulent vulvar discharge were characterized with (PPDS). Overall, the weight average at 18 days in piglets without diarrhea was higher, 4.949g, compared to 4.593g, than piglets with diarrhea. Specifically for litters without diarrhea, the total of weight gain in the treated group was 9.0% (p <0.05) greater than the control group. Tolfenamic acid administered to gilts reduced the piglets mortality during the suckling phase and increased weight gain in litters not affected by diarrhea. The pain and discomfort reduction and in the first days of lactation, contribute to a better litters performance. 

BANKING MEMBERS:
Interno - 1756086 - DIOGENES DEZEN
Presidente - 564.081.370-91 - JALUSA DEON KICH - EMBRAPA
Externo à Instituição - PAULO EDUARDO BENNEMANN - UNOESC