Banca de DEFESA: DIMITRY MACEDONIO FRACARO BALDISSERA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : DIMITRY MACEDONIO FRACARO BALDISSERA
DATE: 17/07/2020
TIME: 09:00
LOCAL: Web Conferência via Google Meet - meet.google.com/swy-kjnv-tyj
TITLE:

Citrate/creatinine ratio “cut-off” reference range in isolated urin samples of healthy dogs.

KEY WORDS:

Hypocitraturia, urinalysis, urolithiasis, crystallization inhibitors, citric acid.

PAGES: 45
BIG AREA: Ciências Agrárias
AREA: Medicina Veterinária
SUMMARY:

The citrate / creatinine ratio serves as a marker of hypocitraturia in the diagnostic aid of urolithiasis in humans. The urolithiasis is an important disease of the domestic canine urinary system, the vast majority of them being composed of calcium oxalate, factors such as the decrease in the concentration of urinary crystallization inhibitors, progressively increase the risk of formation of uroliths, being of great relevance in the diagnostic aid the use of laboratory tests to evaluate cases of urolithiasis, since it is observed relatively frequently and is often relapsing. The purpose of this study was to determine the reference range of the citrate / creatinine ratio in random urine samples in healthy dogs. A total of 46 samples of isolated urine were collected by cystocentesis, catheterization or spontaneous urination of dogs attended at the Center for Clinical and Surgical Practices of the IFC- Campus Concórdia. For this, the animals were divided into groups according to gender, Group I (males n = 17), Group II (females n = 29) and by age group, Group III (adults n = 26) and Group IV (senile n = 20). The male dogs had medians of 12 mg/dL for urinary citrate), urinary creatinine of 64 mg/dL and citrate / creatinine ratio of 0.13; the female dogs 18 mg/dL, 82.3 mg/dL and 0.27, the adults 14.35 mg/dL, 69.10 mg/dL and 0.22 and the senile 15.2 mg/dL, 80.85 mg/dL and 0.13, respectively. To assess the correlation between the age of the animals and the parameters evaluated, Spearman's correlation test was performed (non-normal data). No correlation was found for urinary citrate (r=0.03; p=0.83), urinary creatinine (r=0.16; p=0.26), nor for the urinary citrate / creatinine ratio (r=0.11; p=0.44). However, the values of the citrate / creatinine ratios did not suffer significant variations when compared between the groups, indicating a possible single reference interval for dogs, as occurs with this parameter in human medicine.

BANKING MEMBERS:
Externa à Instituição - MARIA FRANCISCA NEVES - UNESP
Externo à Instituição - HUGO L. R. COSTA - UNESP
Interno - 1755182 - MARIO LETTIERI TEIXEIRA
Presidente - 2408296 - SORAYA REGINA SACCO